| Abstract: |
Patient safety remains a critical global healthcare concern, with approximately 10-12% of hospitalized patients experiencing adverse events annually. This cross-institutional study examined the impact of evidence-based nursing interventions on patient safety outcomes across multiple healthcare facilities in India during 2024-2025. The research employed a quantitative cross-sectional design involving 485 registered nurses from five tertiary care hospitals. Primary objectives focused on evaluating the effectiveness of standardized evidence-based protocols in reducing hospital-acquired infections, medication errors, and fall-related injuries. The hypothesis posited that systematic implementation of evidence-based nursing practices would significantly improve patient safety metrics. Results demonstrated substantial improvements: central line-associated bloodstream infections decreased by 24%, catheter-associated urinary tract infections reduced by 25%, fall rates declined from 2.1 to 1.7 per 1000 patient days, and hand hygiene compliance increased from 64% to 94.6%. Statistical analyses confirmed significant correlations between evidence-based practice implementation and positive patient outcomes (p |